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KMID : 1123920060200041009
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 4 p.1009 ~ p.1013
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Effect of Water Extract of KH-304 on Anti-oxidant and Erectile dysfunction in Old Rat
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Lee Eun-Jeong
Lee Hyun-Ji
Kim Hee-Seok
Hwang Sung-Wan
Hwang Sung-Yeoun
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Abstract
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The fallowing are the result of the experimental studies of KH-304 on the penile nitric oxide synthase (NOS) activity, SOD and the level of blood testosterone in old rat. KH-304 was tested for the expression and activity of eNOS, nNOS, SOD/Mn, caveol in-1, 3 in penis of old-rat. The penile expression level of the five enzyme were increased significantly after oral administration of the KH-304 100mg/kg for 100ays and the concentration of testosterone in the blood were increased. In vitro, the effect of SOD and free radical scavenging were increased significantly. Conclusively, KH-304 is capable of improving of sexual ability in old-rat.
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KEYWORD
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NOS, SOD, Old-rat, testosterone, erectile dysfunction
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